Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Allyl bromide → 4-(Allyloxy)-5-bromo-2-chlorobenzonitrile
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Allyl bromide | HCID 7841 | — |
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | 5-Bromo-2-chloro-4-hydroxybenzonitrile | HCID 53330452 | — |
| 용매 | Acetone | HCID 180 | — |
| 생성물 | 4-(Allyloxy)-5-bromo-2-chlorobenzonitrile | HCID 86714036 | 65% |
반응 단계
A mixture of compound 37 (20.5 g, 88.1 mmol), allyl bromide (11.2 mL, 132 mmol) and K2CO3 (24.4 g, 176 mmol) in acetone (440 mL) was stirred for 3 hours under reflux. The mixture was filtrated and concentrated in vacuo. The resultant was partitioned between EtOAc and water. The organic layer was washed with brine, dried over MgSO4, filtered and concentrated in vacuo. The residue was purified by silica gel column chromatography to afford the product 38 (15.6 g, 65%) as a white solid.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US09371303B2 |
| 출처 데이터셋 | uspto-grants-2016_06 |
| ORD ID | ord-bdbbee18eaab4fd48597365336264816 |
| 출처 메모 | uspto-grants-2016_06 |