Ethyl Acetate → Methyl 2-amino-3-methoxybenzoate

HRID 2206699

반응식

HRID 2206699 반응식
[CH3:1][O:2][C:3]1[C:4]([N+:13]([O-])=O)=[C:5]([CH:10]=[CH:11][CH:12]=1)[C:6]([O:8][CH3:9])=[O:7].CCOC(C)=O>C1COCC1.CO.[Pd]>[NH2:13][C:4]1[C:3]([O:2][CH3:1])=[CH:12][CH:11]=[CH:10][C:5]=1[C:6]([O:8][CH3:9])=[O:7]

참가 물질

6

반응물 2

HCID 8857Ethyl AcetateHCID 79195Benzoic acid, 3-methoxy-2-nitro-, methyl ester

생성물 1

HCID 602320Methyl 2-amino-3-methoxybenzoate수율 99.7%

시약·촉매·용매 3

HCID 23938Palladium촉매HCID 887Methanol용매HCID 8028Tetrahydrofuran용매

실험 절차

A suspension of compound 52 (26.2 g, 124 mmol) and Pd/C (10 wt. %, 6.0 g) in THF (400 mL) and MeOH (200 mL) was stirred under an atmosphere of H2 at room temperature for 18 hours. EtOAc (300 mL) was added to the mixture and filtered through a Celite pad. The filtrate was concentrated in vacuo to provide the crude product 53 (22.4 g, 99%) as colorless oil.

후처리

  1. filtrationfiltered through a Celite pad
  2. concentrationThe filtrate was concentrated in vacuo

출처 및 근거

ORD 기록
ord-f29ead4b9b4b443baed769dc2288e81c
출처 데이터셋
uspto-grants-2016_06
특허 번호
US09371303B2

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