Dimethylformamide → 5-Bromo-2-chloro-3-methoxybenzoyl chloride
반응식
[Br:1][C:2]1[CH:3]=[C:4]([O:12][CH3:13])[C:5]([Cl:11])=[C:6]([CH:10]=1)[C:7](O)=[O:8].CN(C=O)C.C(Cl)(C([Cl:23])=O)=O>C(Cl)Cl>[Br:1][C:2]1[CH:3]=[C:4]([O:12][CH3:13])[C:5]([Cl:11])=[C:6]([CH:10]=1)[C:7]([Cl:23])=[O:8]참가 물질
5
실험 절차
To a solution of compound 56 (3.82 g, 14.3 mmol) in CH2Cl2 (63 mL) was added dropwise DMF (0.20 mL) and (COCl)2 (1.63 mL, 18.7 mmol) at 0° C. under an atmosphere of nitrogen. After being stirred for 20 hours at room temperature, the mixture was concentrated in vacuo to provide the crude acid chloride 59, which was used for the next reaction without further purification.
후처리
- concentrationthe mixture was concentrated in vacuo
출처 및 근거
- ORD 기록
- ord-50c0644bf90848108afdfd7d25d56530
- 출처 데이터셋
- uspto-grants-2016_06
- 특허 번호
- US09371303B2
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