Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Ethylene Glycol → 7-Bromo-4-chloro-2-methyl-2,3-dihydrobenzofuran-5-carbonitrile
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Ethylene Glycol | HCID 174 | — |
| 반응물 | 4-(Allyloxy)-5-bromo-2-chlorobenzonitrile | HCID 86714036 | — |
| 생성물 | 7-Bromo-4-chloro-2-methyl-2,3-dihydrobenzofuran-5-carbonitrile | HCID 71076903 | 52% |
반응 단계
The compound 38 (2.03 g, 7.45 mmol) in ethylene glycol (5 mL) was subjected to microwave conditions (Biotage®) at 250° C. for 90 min. The reaction mixture was cooled to r.t. and extracted with EtOAc/H2O (50 mL/100 mL). The organic layer was dried over MgSO4, filtered off, and evaporated in vacuo. The residue was purified using normal phase column chromatography to obtain the title product (1.05 g, 52%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US09371303B2 |
| 출처 데이터셋 | uspto-grants-2016_06 |
| ORD ID | ord-22a188a88eb0429798d0ffe0eec7b1e9 |
| 출처 메모 | uspto-grants-2016_06 |