3-(Trifluoromethyl)benzylamine → 4-[[3-(Trifluoromethyl)phenyl]methylamino]but-3-en-2-one

반응식

CO[CH:3]=[CH:4][C:5](=[O:7])[CH3:6].[F:8][C:9]([F:19])([F:18])[C:10]1[CH:11]=[C:12]([CH:15]=[CH:16][CH:17]=1)[CH2:13][NH2:14]>>[F:8][C:9]([F:18])([F:19])[C:10]1[CH:11]=[C:12]([CH2:13][NH:14][CH:3]=[CH:4][C:5](=[O:7])[CH3:6])[CH:15]=[CH:16][CH:17]=1

참가 물질

반응물 2

HCID 759623-(Trifluoromethyl)benzylamine

HCID 942973-Buten-2-one, 4-methoxy-

생성물 1

HCID 1317358834-[[3-(Trifluoromethyl)phenyl]methylamino]but-3-en-2-one

실험 절차

The title compound 66 is prepared according to the procedure reported in step A of Example 18 with 4-methoxy-3-buten-2-one (0.2 g, 2 mmol) and 3-trifluoromethylbenzylamine (0.35 g, 2 mmol) as reactants. Yellow oil. (Yield 0.48 g, 100%).

출처 및 근거

ORD 기록: ord-68fe74477521486bb86219ed14a507ae
출처 데이터셋: uspto-grants-2016_06
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US09376387B2

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