Potassium Carbonate → HCID 58683810, 화합물

HRID 220755

반응식

HRID 220755 반응식
[Br:1][C:2]1[CH:3]=[C:4]([CH:7]=[CH:8][C:9]=1[O:10][CH3:11])[CH:5]=[O:6].S([CH2:22][N+:23]#[C-:24])(C1C=CC(C)=CC=1)(=O)=O.C([O-])([O-])=O.[K+].[K+]>CO>[Br:1][C:2]1[CH:3]=[C:4]([C:5]2[O:6][CH:24]=[N:23][CH:22]=2)[CH:7]=[CH:8][C:9]=1[O:10][CH3:11]

참가 물질

5

반응물 3

HCID 11430Potassium CarbonateHCID 986623-Bromo-4-methoxybenzaldehydeHCID 161915Tosylmethyl isocyanide

생성물 1

HCID 58683810HCID 58683810, 화합물수율 80.4%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

The mixed solution of 3-bromo-4-methoxybenzaldehyde (200 mg, 0.93 mmol) in methanol (4 mL) was added tosylmethyl isocyanide (200 mg, 1.02 mmol) and K2CO3 (260 mg, 1.88 mmol). The reaction was stirred at room temperature for 5 min before heated to 80° C. in the sealed tube. After 30 min, the solution was cooled to room temperature and concentrated. Column chromatography afforded 5-(3-bromo-4-methoxyphenyl)oxazole (o) (190 mg, 80%). Following the procedures analogous to the Suzuki and amide coupling reactions described for Compound 20, Compound 25 was prepared.

후처리

  1. temperaturebefore heated to 80° C. in the sealed tube
  2. waitAfter 30 min
  3. temperaturethe solution was cooled to room temperature
  4. concentrationconcentrated

출처 및 근거

ORD 기록
ord-b408120d9c7e404abd0bb2bc574e6ca7
출처 데이터셋
uspto-grants-2012_06
특허 번호
US08202999B2

연결된 노트

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