Sodium Azide → 4-Azidomethyl-3-fluorobenzoic acid methyl ester
반응식
[N-:1]=[N+:2]=[N-:3].[Na+].[CH3:5][O:6][C:7](=[O:17])[C:8]1[CH:13]=[CH:12][C:11]([CH2:14]Br)=[C:10]([F:16])[CH:9]=1>CN(C=O)C.CCOC(C)=O>[CH3:5][O:6][C:7](=[O:17])[C:8]1[CH:13]=[CH:12][C:11]([CH2:14][N:1]=[N+:2]=[N-:3])=[C:10]([F:16])[CH:9]=1참가 물질
5
실험 절차
Sodium azide (609 mg) was added to a solution of 4-bromomethyl-3-fluorobenzoic acid methyl ester from Example E3.2 (2.1 g, 8.5 mmol) in DMF (30 ml). The mixture was stirred for 18 h, diluted with EtOAc, washed with water and brine and concentrated in vacuo to give a colourless oil identified as the title compound (1.8 g, 100%).
후처리
- washwashed with water and brine
- concentrationconcentrated in vacuo
- customto give a colourless oil
출처 및 근거
- ORD 기록
- ord-e9a6428177bc43d1a2905c16a88ea4c3
- 출처 데이터셋
- uspto-grants-2012_06
- 특허 번호
- US08202858B2
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