HCID 178432322, 화합물 → HCID 178432321, 화합물
반응식
C([N:9]1[CH2:18][CH2:17][C:16]2[N:15]=[C:14]([CH3:19])[NH:13][C:12]=2[C:11]2[CH:20]=[CH:21][CH:22]=[CH:23][C:10]1=2)(=O)C1C=CC=CC=1>Cl.O1CCOCC1>[CH3:19][C:14]1[NH:13][C:12]2[C:11]3[CH:20]=[CH:21][CH:22]=[CH:23][C:10]=3[NH:9][CH2:18][CH2:17][C:16]=2[N:15]=1참가 물질
3
실험 절차
6-Benzoyl-2-methyl-1,4,5,6-tetrahydro-1,3,6-triaza-benzo[e]azulene from Example E5.8 (160 mg, 0.53 mmol) was dissolved in a 6M HCl/dioxan solution (50 ml) and heated at reflux for 18 h. The reaction mixture was cooled to room temperature and reduced in vacuo. The residue was partitioned between EtOAc and saturated NaHCO3 (aq) and the layers were separated. The organic layer was washed with brine, dried, filtered and reduced in vacuo to yield the title compound (69 mg, 66%).
후처리
- temperatureheated
- temperatureat reflux for 18 h
- customThe residue was partitioned between EtOAc and saturated NaHCO3 (aq)
- customthe layers were separated
- washThe organic layer was washed with brine
- customdried
- filtrationfiltered
출처 및 근거
- ORD 기록
- ord-c1733d20b31143ce812564b0425f889a
- 출처 데이터셋
- uspto-grants-2012_06
- 특허 번호
- US08202858B2
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