Thionyl Chloride → 3-(3-Bromo-4-fluoro-phenyl)-acryloyl chloride

HRID 2207879노트

반응식

HRID 2207879 반응식
[Br:1][C:2]1[CH:3]=[C:4]([CH:9]=[CH:10][C:11]([OH:13])=O)[CH:5]=[CH:6][C:7]=1[F:8].S(Cl)([Cl:16])=O>>[Br:1][C:2]1[CH:3]=[C:4]([CH:9]=[CH:10][C:11]([Cl:16])=[O:13])[CH:5]=[CH:6][C:7]=1[F:8]

참가 물질

3

반응물 2

HCID 24386Thionyl ChlorideHCID 6883113-(3-Bromo-4-fluorophenyl)-2-propenoic acid

생성물 1

HCID 27569963-(3-Bromo-4-fluoro-phenyl)-acryloyl chloride

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온도
100 °C

실험 절차

3-(3-Bromo-4-fluoro-phenyl)-acrylic acid (3.3 g, 13.3 mmol) prepared in Step 1 was added to thionyl chloride (10.0 mL). The reaction mixture was stirred at 100° C. for 2 hours, concentrated under reduced pressure. The resulting residue was concentrated under reduced pressure three times, along with using toluene, to give 3.5 g of the titled compound as an unpurified dark brown liquid.

후처리

  1. concentrationconcentrated under reduced pressure
  2. concentrationThe resulting residue was concentrated under reduced pressure three times, along with using toluene

출처 및 근거

ORD 기록
ord-1bc6024e22d84855b8396c2585ada29d
출처 데이터셋
uspto-grants-2016_06
특허 번호
US09376420B2

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