tert-Butyl[(1R*,3R*,4R*)-4-azido-3-methylcyclohexyl]carbamate → tert-butyl[(1R*,3R*,4R*)-4-amino-3-methylcyclohexyl]carbamate
반응식
[N:1]([C@@H:4]1[CH2:9][CH2:8][C@@H:7]([NH:10][C:11](=[O:17])[O:12][C:13]([CH3:16])([CH3:15])[CH3:14])[CH2:6][C@H:5]1[CH3:18])=[N+]=[N-]>CO.[Pd]>[NH2:1][C@@H:4]1[CH2:9][CH2:8][C@@H:7]([NH:10][C:11](=[O:17])[O:12][C:13]([CH3:15])([CH3:14])[CH3:16])[CH2:6][C@H:5]1[CH3:18]참가 물질
4
실험 절차
tert-Butyl [(1R*,3R*,4R*)-4-azido-3-methylcyclohexyl]carbamate (example 010; 1.2 g; 4.7 mmol) is dissolved in MeOH (20.0 mL) and pressure hydrogenated over Pd (10% on charcoal; 0.1 g) at 20 bar and ambient temperature over night. After filtration through a pad of celite the solvent is removed under reduced pressure to yield 1.0 g of the title compound as off-white solid.
후처리
- filtrationAfter filtration through a pad of celite the solvent
- customis removed under reduced pressure
출처 및 근거
- ORD 기록
- ord-9fda06db06ff4ad38ae76f856aaafaa3
- 출처 데이터셋
- uspto-grants-2016_06
- 특허 번호
- US09376442B2
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