Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Ethanol → Ethyl 3-fluoro-4-hydroxybenzoate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Ethanol | HCID 702 | — |
| 반응물 | Sulfuric Acid | HCID 1118 | — |
| 반응물 | 3-Fluoro-4-hydroxybenzoic acid | HCID 160456 | — |
| 생성물 | Ethyl 3-fluoro-4-hydroxybenzoate | HCID 13745619 | 85% |
반응 단계
A solution of 3-fluoro-4-hydroxy-benzoic acid (5.16 g, 33.1 mmol) in ethanol (100 ml) was treated with conc. sulphuric acid (5 ml), and the mixture heated at reflux for 4 days. The volatiles were removed in vacuo, and the aqueous residue was basified with saturated NaHCO3 and extracted twice with diethyl ether. The combined organic extracts were dried and concentrated in vacuo to yield the title compound (5.16 g, 85%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08202858B2 |
| 출처 데이터셋 | uspto-grants-2012_06 |
| ORD ID | ord-9c84b9f0d9cf4aa3ae0ff39ecb8f6250 |
| 출처 메모 | uspto-grants-2012_06 |