tert-butyl (3s,4s)-3-amino-4-hydroxypiperidine-1-carboxylate → HCID 67955645, 화합물

HRID 2208217노트

반응식

HRID 2208217 반응식
[CH:1]1([CH2:4][O:5][C:6]2[CH:11]=[C:10]([F:12])[C:9]([O:13][CH3:14])=[CH:8][C:7]=2[C:15]2[C:16]3[N:23]([CH2:24][O:25][CH2:26][CH2:27][Si:28]([CH3:31])([CH3:30])[CH3:29])[C:22]([CH3:32])=[C:21]([C:33](O)=[O:34])[C:17]=3[N:18]=[CH:19][N:20]=2)[CH2:3][CH2:2]1.[NH2:36][C@@H:37]1[C@@H:42]([OH:43])[CH2:41][CH2:40][N:39]([C:44]([O:46][C:47]([CH3:50])([CH3:49])[CH3:48])=[O:45])[CH2:38]1>>[CH:1]1([CH2:4][O:5][C:6]2[CH:11]=[C:10]([F:12])[C:9]([O:13][CH3:14])=[CH:8][C:7]=2[C:15]2[C:16]3[N:23]([CH2:24][O:25][CH2:26][CH2:27][Si:28]([CH3:30])([CH3:31])[CH3:29])[C:22]([CH3:32])=[C:21]([C:33]([NH:36][C@@H:37]4[C@@H:42]([OH:43])[CH2:41][CH2:40][N:39]([C:44]([O:46][C:47]([CH3:50])([CH3:49])[CH3:48])=[O:45])[CH2:38]4)=[O:34])[C:17]=3[N:18]=[CH:19][N:20]=2)[CH2:3][CH2:2]1

참가 물질

3

반응물 2

HCID 67032897tert-butyl (3s,4s)-3-amino-4-hydroxypiperidine-1-carboxylateHCID 67956889HCID 67956889, 화합물

생성물 1

HCID 67955645HCID 67955645, 화합물

실험 절차

Starting from 4-[2-(cyclopropylmethoxy)-4-fluoro-5-methoxyphenyl]-6-methyl-5-{[2-(trimethylsilyl)ethoxy]methyl}-5H-pyrrolo[3,2-d]pyrimidine-7-carboxylic acid (example D.c10) and tert-butyl (3S*,4S*)-3-amino-4-hydroxy-piperidine-1-carboxylate (Example C3) the title compound is obtained as pale yellow viscous oil.

출처 및 근거

ORD 기록
ord-0faae8ae2b0c45aab0c71d3ced426d11
출처 데이터셋
uspto-grants-2016_06
특허 번호
US09376442B2

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