HCID 67033074, 화합물 → HCID 178429357, 화합물

반응식

[CH:1]1([CH2:4][O:5][C:6]2[CH:11]=[CH:10][C:9]([C:12]3([CH3:17])[O:16][CH2:15][CH2:14][O:13]3)=[CH:8][C:7]=2[C:18]2[C:19]3[N:26]([CH2:27][O:28][CH2:29][CH2:30][Si:31]([CH3:34])([CH3:33])[CH3:32])[C:25]([CH3:35])=[C:24]([C:36](O)=[O:37])[C:20]=3[N:21]=[CH:22][N:23]=2)[CH2:3][CH2:2]1.[NH2:39][C@H:40]1[CH2:45][CH2:44][C@H:43]([NH:46][C:47](=[O:53])[O:48][C:49]([CH3:52])([CH3:51])[CH3:50])[CH2:42][CH2:41]1>>[CH:1]1([CH2:4][O:5][C:6]2[CH:11]=[CH:10][C:9]([C:12]3([CH3:17])[O:16][CH2:15][CH2:14][O:13]3)=[CH:8][C:7]=2[C:18]2[C:19]3[N:26]([CH2:27][O:28][CH2:29][CH2:30][Si:31]([CH3:34])([CH3:32])[CH3:33])[C:25]([CH3:35])=[C:24]([C:36]([NH:39][C@H:40]4[CH2:45][CH2:44][C@H:43]([NH:46][C:47](=[O:53])[O:48][C:49]([CH3:51])([CH3:50])[CH3:52])[CH2:42][CH2:41]4)=[O:37])[C:20]=3[N:21]=[CH:22][N:23]=2)[CH2:2][CH2:3]1

참가 물질

반응물 2

HCID 67033074HCID 67033074, 화합물

HCID 178419079HCID 178419079, 화합물

생성물 1

HCID 178429357HCID 178429357, 화합물

실험 절차

Starting from 4-[2-(cyclopropylmethoxy)-5-(2-methyl-1,3-dioxolan-2-yl)phenyl]-6-methyl-5-{[2-(trimethylsilyl)ethoxy]methyl}-5H-pyrrolo[3,2-d]pyrimidine-7-carboxylic acid (example D.c13) and commercially available tert-butyl trans-(4-amino-cyclohexyl)-carbamate the title compound is obtained as pale yellow viscous oil.

출처 및 근거

ORD 기록: ord-5e75b025609e43d0859ba770f65b6b4e
출처 데이터셋: uspto-grants-2016_06
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US09376442B2

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