Trifluoroacetic acid → 2-(4-(Methoxycarbonyl)-2-methylphenyl)acetic acid

HRID 220828노트

반응식

HRID 220828 반응식
FC(F)(F)C(O)=O.[CH3:8][O:9][C:10](=[O:26])[C:11]1[CH:16]=[CH:15][C:14]([CH2:17][C:18]([O:20]C(C)(C)C)=[O:19])=[C:13]([CH3:25])[CH:12]=1>ClCCl>[CH3:8][O:9][C:10](=[O:26])[C:11]1[CH:16]=[CH:15][C:14]([CH2:17][C:18]([OH:20])=[O:19])=[C:13]([CH3:25])[CH:12]=1

참가 물질

4

반응물 2

HCID 6422Trifluoroacetic acidHCID 575554334-Tert-butoxycarbonylmethyl-3-methyl-benzoic acid methyl ester

생성물 1

HCID 575552242-(4-(Methoxycarbonyl)-2-methylphenyl)acetic acid수율 81%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

Trifluoroacetic acid (15 ml) was added to a solution of 4-tert-butoxycarbonylmethyl-3-methyl-benzoic acid methyl ester from Example E32.1 (2.84 g, 10.7 mmol) in dichloromethane (15 ml). The mixture was stirred for 90 min at room temperature, concentrated in vacuo and azeotroped with toluene. The residue was recrystallised from EtOAc and hexane to yield the title compound (1.81 g, 81%).

후처리

  1. concentrationconcentrated in vacuo
  2. customazeotroped with toluene
  3. customThe residue was recrystallised from EtOAc and hexane

출처 및 근거

ORD 기록
ord-40ffc1f9c1c244aa81ff6b3c5a9e1bdd
출처 데이터셋
uspto-grants-2012_06
특허 번호
US08202858B2

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