Nitric Acid → Methyl 5-bromo-2-methyl-3-nitrobenzoic acid

HRID 2208748

반응식

HRID 2208748 반응식
[Br:1][C:2]1[C:3]([CH3:12])=[CH:4][C:5]([CH3:11])=[C:6]([CH:10]=1)[C:7]([OH:9])=[O:8].OS(O)(=O)=O.[N+:18]([O-])([OH:20])=[O:19]>>[Br:1][C:2]1[C:3]([CH3:12])=[C:4]([N+:18]([O-:20])=[O:19])[C:5]([CH3:11])=[C:6]([CH:10]=1)[C:7]([OH:9])=[O:8]

참가 물질

4

반응물 3

HCID 944Nitric AcidHCID 1118Sulfuric Acid2회HCID 5557655-Bromo-2,4-dimethylbenzoic acid

생성물 1

HCID 86623945Methyl 5-bromo-2-methyl-3-nitrobenzoic acid수율 91%

반응 조건

온도
-10 °C

실험 절차

5-Bromo-2,4-dimethylbenzoic acid (12 g, 52.17 mmol) was added to cooled conc. H2SO4 (48 mL) at −10° C. lot wise. After 10 minutes nitrating mixture {prepared as mixing Conc. HNO3 (6 mL) with conc.H2SO4 (24 mL)} was added drop wise at −10° C. Resulting reaction mass was stirred at −10° C. for 30 minutes. On completion, reaction mixture was poured on ice cold water, solid precipitated was filtered, washed with water and dried under vacuum giving desired compound (13 g, 91%).

후처리

  1. custommixture {prepared
  2. customResulting
  3. customreaction mass
  4. customOn completion, reaction mixture
  5. additionwas poured on ice cold water, solid
  6. customprecipitated
  7. filtrationwas filtered
  8. washwashed with water
  9. customdried under vacuum

출처 및 근거

ORD 기록
ord-605d50c7682244c88c1ca871eeafdb64
출처 데이터셋
uspto-grants-2016_06
특허 번호
US09376422B2

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