Ammonium Chloride → 6-bromo-2-chloro-N3-methylpyridine-3,4-diamine
반응식
[Br:1][C:2]1[N:7]=[C:6]([Cl:8])[C:5]([NH:9][CH3:10])=[C:4]([N+:11]([O-])=O)[CH:3]=1.[Cl-].[NH4+]>C(O)C.O.CCOC(C)=O.[Fe]>[Br:1][C:2]1[N:7]=[C:6]([Cl:8])[C:5]([NH:9][CH3:10])=[C:4]([NH2:11])[CH:3]=1참가 물질
7
반응 조건
- 온도
- 140 °C
실험 절차
To a solution of 6-bromo-2-chloro-N-methyl-4-nitropyridin-3-amine 2.59 (1 g, 3.75 mmol) in ethanol (10 ml) was added Fe powder (1.05 g, 18.7 mmol) and a solution of ammonium chloride (1 g, 18.8 mmol) in water (3 mL). The mixture was heated in microwave at 140° C. for 30 min. The mixture was then diluted with EtOAc, filtered and evaporated to give 6-bromo-2-chloro-N3-methylpyridine-3,4-diamine 2.59-A, which was used in the next step without purification.
후처리
- filtrationfiltered
- customevaporated
출처 및 근거
- ORD 기록
- ord-2501c82646ee494491e5bc533971e776
- 출처 데이터셋
- uspto-grants-2016_06
- 특허 번호
- US09376441B2
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