Thionyl Chloride → HCID 19035209, 화합물

반응식

[F:1][C:2]1[C:10]([C:11]([F:14])([F:13])[F:12])=[C:9]([F:15])[CH:8]=[CH:7][C:3]=1[C:4](O)=[O:5].S(Cl)([Cl:18])=O>>[F:1][C:2]1[C:10]([C:11]([F:14])([F:13])[F:12])=[C:9]([F:15])[CH:8]=[CH:7][C:3]=1[C:4]([Cl:18])=[O:5]

참가 물질

반응물 2

HCID 24386Thionyl Chloride

HCID 97945292,4-difluoro-3-(trifluoromethyl)benzoic Acid

생성물 1

HCID 19035209HCID 19035209, 화합물

반응 조건

온도: 50 °C

실험 절차

19.3 g (0.085 mol) of 2,4-difluoro-3-trifluoromethylbenzoic acid are added in portions at room temperature to 130 ml of thionyl chloride. After metering has ended, the mixture is heated at 50° C. until the evolution of gas has ceased. The excess thionyl chloride is then removed by distillation and the crude product is reacted further directly.

후처리

customThe excess thionyl chloride is then removed by distillation
customthe crude product is reacted further directly

출처 및 근거

ORD 기록: ord-2f5d5cf8c6624651ad1aacee2d8e1d7a
출처 데이터셋: uspto-grants-1995_10
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US05457104

반응 노트

불러오는 중…