1,1'-Carbonyldiimidazole → 3-[4-(2-pyridylthio)butyl]quinazoline-2,4(1H,3H)-dione

HRID 2210188노트

반응식

HRID 2210188 반응식
[NH2:1][C:2]1[CH:21]=[CH:20][CH:19]=[CH:18][C:3]=1[C:4]([NH:6][CH2:7][CH2:8][CH2:9][CH2:10][S:11][C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][N:13]=1)=[O:5].[C:22](N1C=CN=C1)(N1C=CN=C1)=[O:23]>O1CCCC1>[N:13]1[CH:14]=[CH:15][CH:16]=[CH:17][C:12]=1[S:11][CH2:10][CH2:9][CH2:8][CH2:7][N:6]1[C:4](=[O:5])[C:3]2[C:2](=[CH:21][CH:20]=[CH:19][CH:18]=2)[NH:1][C:22]1=[O:23]

참가 물질

4

반응물 2

HCID 682631,1'-CarbonyldiimidazoleHCID 19079132HCID 19079132, 화합물

생성물 1

HCID 190791813-[4-(2-pyridylthio)butyl]quinazoline-2,4(1H,3H)-dione수율 68.8%

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

Under nitrogen atmosphere, to a solution of 452 mg (1.5 mmol) of 2-[4-(2-aminobenzoylamino)butylthio]pyridine in 20 ml of tetrahydrofuran, 486 mg (3.0 mmol) of 1,1'-carbonyldiimidazole was added, and the mixture was stirred at room temperature for 16 hours. The solvent was distilled off and the residue was dissolved in chloroform. The solution was washed with water and dried. The solvent was distilled off and the residue was recrystallized from chloroform/ether to give 337 mg of the desired product (68.8% yield, white crystals).

후처리

  1. distillationThe solvent was distilled off
  2. dissolutionthe residue was dissolved in chloroform
  3. washThe solution was washed with water
  4. customdried
  5. distillationThe solvent was distilled off
  6. customthe residue was recrystallized from chloroform/ether

출처 및 근거

ORD 기록
ord-5dadb6a948554c6386b0454dc403c74a
출처 데이터셋
uspto-grants-1995_10
특허 번호
US05457106

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