Methyl 4-(2-aminopropyl)benzoate → N-[2-(4-Carbomethoxyphenyl)-1-methylethyl]-2-hydroxy-2-(thiazol-4-yl)ethanamine

HRID 2210346노트

반응식

HRID 2210346 반응식
[C:1]([C:5]1[CH:10]=[CH:9][C:8]([CH2:11][CH:12]([NH2:14])[CH3:13])=[CH:7][CH:6]=1)([O:3][CH3:4])=[O:2].Br[CH2:16][C:17]([C:19]1[N:20]=[CH:21][S:22][CH:23]=1)=[O:18]>>[C:1]([C:5]1[CH:10]=[CH:9][C:8]([CH2:11][CH:12]([NH:14][CH2:16][CH:17]([OH:18])[C:19]2[N:20]=[CH:21][S:22][CH:23]=2)[CH3:13])=[CH:7][CH:6]=1)([O:3][CH3:4])=[O:2]

참가 물질

3

반응물 2

HCID 15034329Methyl 4-(2-aminopropyl)benzoateHCID 199741722-Bromo-1-(thiazol-4-yl)ethanone

생성물 1

HCID 19380205N-[2-(4-Carbomethoxyphenyl)-1-methylethyl]-2-hydroxy-2-(thiazol-4-yl)ethanamine

실험 절차

Prepared analogously to Example 3 by reaction of 2-(4-carbomethoxyphenyl)-1-methylethylamine with 4-bromoacetyl-thiazole, followed by reduction and purification of the base on a silica gel plate using ethyl acetate/methanol =8:2 as eluant.

후처리

  1. customfollowed by reduction and purification of the base on a silica gel plate

출처 및 근거

ORD 기록
ord-e887a9edc56c43fa8726e4c03bf109b8
출처 데이터셋
uspto-grants-1995_10
특허 번호
US05457205

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