Morpholine → 173158-11-7

HRID 2210470노트

반응식

HRID 2210470 반응식
[C:1]([C:4]1[CH:5]=[C:6]([S:10](F)(=[O:12])=[O:11])[CH:7]=[CH:8][CH:9]=1)(=[O:3])[CH3:2].[NH:14]1[CH2:19][CH2:18][O:17][CH2:16][CH2:15]1>C1COCC1>[C:1]([C:4]1[CH:5]=[C:6]([S:10]([N:14]2[CH2:19][CH2:18][O:17][CH2:16][CH2:15]2)(=[O:12])=[O:11])[CH:7]=[CH:8][CH:9]=1)(=[O:3])[CH3:2]

참가 물질

4

반응물 2

HCID 8083MorpholineHCID 128213-Acetylbenzenesulfonyl fluoride

생성물 1

HCID 962213173158-11-7

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

A solution of 20.02 g (0.1 mol) of 3-acetylbenzenesulfonyl fluoride and 29 ml of morpholine in 100 mL of THF is stirred at room temperature for 16 hours. The solvent is removed, the residue dissolved in CH2C2, and solution washed with H20 and 2N HCl. The organic layer is dried (MgSO4), the solvent removed, and the residue crystallized from CH2Cl2 -hexane to give 25.2 g (93%) of light yellow crystals, m.p. 144°-147° C.

후처리

  1. customThe solvent is removed
  2. dissolutionthe residue dissolved in CH2C2, and solution
  3. washwashed with H20 and 2N HCl
  4. dry with materialThe organic layer is dried (MgSO4)
  5. customthe solvent removed
  6. customthe residue crystallized from CH2Cl2 -hexane
  7. customto give 25.2 g (93%) of light yellow crystals, m.p. 144°-147° C.

출처 및 근거

ORD 기록
ord-c2644188701d44138328be6033010647
출처 데이터셋
uspto-grants-1995_10
특허 번호
US05459131

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