2-Nitroaniline → Benzenemethanamine, 4-fluoro-N-(2-nitrophenyl)-

HRID 2210829노트

반응식

HRID 2210829 반응식
[N+:1]([C:4]1[CH:10]=[CH:9][CH:8]=[CH:7][C:5]=1[NH2:6])([O-:3])=[O:2].[F:11][C:12]1[CH:19]=[CH:18][C:15]([CH2:16]Cl)=[CH:14][CH:13]=1>C(C(C)=O)C>[F:11][C:12]1[CH:19]=[CH:18][C:15]([CH2:16][NH:6][C:5]2[CH:7]=[CH:8][CH:9]=[CH:10][C:4]=2[N+:1]([O-:3])=[O:2])=[CH:14][CH:13]=1

참가 물질

4

반응물 2

HCID 69462-NitroanilineHCID 96024-Fluorobenzyl chloride

생성물 1

HCID 11311160Benzenemethanamine, 4-fluoro-N-(2-nitrophenyl)-

시약·촉매·용매 1

HCID 6569Methyl Ethyl Ketone용매

실험 절차

56 g N-(4-fluorobenzyl) 2-nitroaniline are reduced in the presence of 34 g of 5% palladized charcoal into methanol (560 ml) using a stream of hydrogen at room temperature and normal pression. After achievement of the reaction, the mixture is washed with nitrogen, filtered on clay (Trade Mark Celite) and concentrated to dryness. The residue is recrystallized from isopropyl ether. The desired N-substituted phenylene diamine, is thus obtained recovered weight: 38.5 g. The starting material N-(4-fluorobenzyl) 2-nitroaniline is prepared by alkylating the 2-nitroaniline by means of 4-fluorobenzyl chloride in the methyl ethyl ketone.

후처리

  1. customrecovered weight

출처 및 근거

ORD 기록
ord-71b6a4a453dd4985aa36bbdea00cf675
출처 데이터셋
uspto-grants-1995_10
특허 번호
US05461059

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