3-nitro-5,6,7,8-tetrahydroquinoline → 5,6,7,8-tetrahydroquinolin-3-amine

HRID 2210888노트

반응식

HRID 2210888 반응식
[N+:1]([C:4]1[CH:5]=[N:6][C:7]2[CH2:8][CH2:9][CH2:10][CH2:11][C:12]=2[CH:13]=1)([O-])=O>CO.[C].[Pd]>[NH2:1][C:4]1[CH:5]=[N:6][C:7]2[CH2:8][CH2:9][CH2:10][CH2:11][C:12]=2[CH:13]=1

참가 물질

4

반응물 1

HCID 110303733-nitro-5,6,7,8-tetrahydroquinoline

생성물 1

HCID 106543695,6,7,8-tetrahydroquinolin-3-amine수율 97.1%

시약·촉매·용매 2

HCID 178418390HCID 178418390, 화합물촉매HCID 887Methanol용매

실험 절차

A suspension of 15.8 g of 3-nitro-5,6,7,8-tetrahydroquinoline [synthesized according to the method as described in Bull. Chem. Soc. Jpn. Vol. 63 (1990), 2820]and 1.6 g of 5% palladium carbon in 300 ml of methanol is hydrogenerated at ordinary temperature under atmospheric pressure. The catalyst is filtered off, and the filtrate is concentrated in vacuo to remove the solvent. The resultant crude product is recrystallized from methylene chloride-isopropyl ether to give 12.76 g of the titled compound 1. Yield: 97% mp.: 97° to 98° C.

후처리

  1. customsynthesized
  2. filtrationThe catalyst is filtered off
  3. concentrationthe filtrate is concentrated in vacuo
  4. customto remove the solvent
  5. customThe resultant crude product is recrystallized from methylene chloride-isopropyl ether

출처 및 근거

ORD 기록
ord-c1080f1dd6244c8fb91f1f9382e55657
출처 데이터셋
uspto-grants-1995_10
특허 번호
US05461062

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