Triethylamine → 1-(Methylthiomethyl)-6-phenylthiothymine

HRID 2210899

반응식

HRID 2210899 반응식
Cl[CH2:2][S:3][CH3:4].[C:5]1([C:11]2[NH:16][C:15](=[S:17])[NH:14][C:13](=[O:18])[C:12]=2[CH3:19])[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1.C(N(CC)CC)C>CN(C)C=O>[CH3:4][S:3][CH2:2][N:16]1[C:11]([C:5]2[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=2)=[C:12]([CH3:19])[C:13](=[O:18])[NH:14][C:15]1=[S:17]

참가 물질

5

반응물 3

HCID 8471TriethylamineHCID 16916Chloromethyl methyl sulfideHCID 186710275-Methyl-6-phenyl-2-sulfanylidene-1,2,3,4-tetrahydropyrimidin-4-one

생성물 1

HCID 538403951-(Methylthiomethyl)-6-phenylthiothymine수율 8.1%

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

To 4 ml of dimethylformamide, 0.17 ml (2.0 mmol) of chloromethylmethylsulfide, 0.47 g (2.0 mmol) of 6-phenylthiothymine, 0.56 ml (2.0 mmol) of triethylamine were added and allowed to react for 22 hours at room temperature. The reaction mixture was concentrated under reduced pressure and the residue was adsorbed on a silica gel column and eluted with chloroform. The eluate was concentrated and crystallized from ethyl acetate to obtain 45 mg of the target compound (Yield: 8%).

후처리

  1. customto react for 22 hours at room temperature
  2. concentrationThe reaction mixture was concentrated under reduced pressure
  3. washeluted with chloroform
  4. concentrationThe eluate was concentrated
  5. customcrystallized from ethyl acetate

출처 및 근거

ORD 기록
ord-5ca7112b5bda41a4b4713ca3e693ec49
출처 데이터셋
uspto-grants-1995_10
특허 번호
US05461060

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