Water → 2-(2-Decylindan-5-yl)-5-(3-phenylpropyloxy)pyrimidine

HRID 2211073

반응식

HRID 2211073 반응식
[CH2:1]([CH:11]1[CH2:19][C:18]2[C:13](=[CH:14][CH:15]=[C:16]([C:20]3[N:25]=[CH:24][C:23]([OH:26])=[CH:22][N:21]=3)[CH:17]=2)[CH2:12]1)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH3:10].C1(C)C=CC(S(O[CH2:37][CH2:38][CH2:39][C:40]2[CH:45]=[CH:44][CH:43]=[CH:42][CH:41]=2)(=O)=O)=CC=1.[OH-].[K+].O>C(O)C>[CH2:1]([CH:11]1[CH2:19][C:18]2[C:13](=[CH:14][CH:15]=[C:16]([C:20]3[N:25]=[CH:24][C:23]([O:26][CH2:37][CH2:38][CH2:39][C:40]4[CH:45]=[CH:44][CH:43]=[CH:42][CH:41]=4)=[CH:22][N:21]=3)[CH:17]=2)[CH2:12]1)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH3:10]

참가 물질

6

반응물 4

HCID 962WaterHCID 14797Potassium HydroxideHCID 109899213-Phenylpropyl 4-methylbenzenesulfonateHCID 193753532-(2-Decylindan-5-yl)pyrimidine-5-ol

생성물 1

HCID 193753602-(2-Decylindan-5-yl)-5-(3-phenylpropyloxy)pyrimidine수율 56.3%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

0.443 g of 2-(2-decylindan-5-yl)pyrimidine-5-ol, 0.343 g of phenylpropyl p-toluenesulfonate and 0.1 g of potassium hydroxide were dissolved in 2 ml of ethanol, followed by heat-refluxing for 4 hours. After the reaction, the reaction mixture was poured into water and subjected to extraction with toluene. The resultant organic layer was washed with water and dried with anhydrous sodium sulfate, followed by distilling-off of the solvent and purification by silica gel column chromatography to obtain 0.313 g of an objective product (Yield: 53.2%).

후처리

  1. temperatureby heat-refluxing for 4 hours
  2. customAfter the reaction
  3. extractionsubjected to extraction with toluene
  4. washThe resultant organic layer was washed with water
  5. dry with materialdried with anhydrous sodium sulfate
  6. distillationfollowed by distilling-off of the solvent and purification by silica gel column chromatography

출처 및 근거

ORD 기록
ord-7a8d88ac4e4845b1bd644afc12d679ed
출처 데이터셋
uspto-grants-1995_10
특허 번호
US05462694

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