참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Hydrazine hydrate (1:1) | HCID 24654 | — |
| 반응물 | Methyl 2-[[3-(trifluoromethyl)phenyl]amino]benzoate | HCID 200813 | — |
| 용매 | Methanol | HCID 887 | — |
| 생성물 | 2-[(3-Trifluoromethylphenyl)amino]benzoic acid hydrazide | HCID 13167827 | 52% |
반응 단계
Hydrazine hydrate (14 ml) is added dropwise to a solution of methyl 2-[(3-trifluoromethylphenyl)amino]-benzoate (1.463 g, 4.95 mmol) in 70 ml of methanol. The reaction solution is heated at 60° C. under an inert atmosphere for two hours and then concentrated in vacuo and chromatographed, eluting with ethyl acetate and hexane (1:1), providing 763.0 mg (52%) of a white solid, mp 134°-135° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US05462952 |
|---|
| 출처 데이터셋 | uspto-grants-1995_10 |
|---|
| ORD ID | ord-ec0817b0d4fe4fb1959084b2d4b65fbf |
|---|
| 출처 메모 | uspto-grants-1995_10 |
|---|
