Dimethylformamide → Ethyl 2-(2-cyanoanilino)acetate
반응식
[C:1]([NH2:10])(=O)[C:2]1[C:3](=[CH:5][CH:6]=[CH:7][CH:8]=1)[NH2:4].C(=O)([O-])[O-].[K+].[K+].Br[CH2:18][C:19]([O:21][CH2:22][CH3:23])=[O:20].CN(C)C=O>O>[CH2:22]([O:21][C:19](=[O:20])[CH2:18][NH:4][C:3]1[CH:5]=[CH:6][CH:7]=[CH:8][C:2]=1[C:1]#[N:10])[CH3:23]참가 물질
6
실험 절차
A mixture of anthranilamide (11.8 g), potassium carbonate (20 g), ethyl bromoacetate (18 g) and dimethylformamide (50 mL) was heated at reflux for 40 min. The reaction mixture was diluted with water and the product was extracted with ether. The organic layer was washed with water and brine, dried over magnesium sulfate and the solvent was removed in vacuo. The residue was recrystallized from ethanol to afford N-(2-Cyanophenyl)glycine ethyl ester as a colorless solid.
후처리
- temperaturewas heated
- temperatureat reflux for 40 min
- extractionthe product was extracted with ether
- washThe organic layer was washed with water and brine
- dry with materialdried over magnesium sulfate
- customthe solvent was removed in vacuo
- customThe residue was recrystallized from ethanol
출처 및 근거
- ORD 기록
- ord-0494ca7b1ef848e8bd34213818a8f1ac
- 출처 데이터셋
- uspto-grants-1995_10
- 특허 번호
- US05463054
반응 노트
불러오는 중…