Ethyl 2-(2-cyanoanilino)acetate → Ethyl 3-amino-1H-indole-2-carboxylate
반응식
[CH2:1]([O:3][C:4](=[O:15])[CH2:5][NH:6][C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][C:8]=1[C:13]#[N:14])[CH3:2].CC(C)([O-])C.[K+]>C1COCC1.[Cl-].[NH4+]>[NH2:14][C:13]1[C:8]2[C:7](=[CH:12][CH:11]=[CH:10][CH:9]=2)[NH:6][C:5]=1[C:4]([O:3][CH2:1][CH3:2])=[O:15]참가 물질
5
실험 절차
To a solution of N-(2-Cyanophenyl)glycine ethyl ester (8.1 g) in THF (125 mL) was added potassium t-butoxide (4.5 g) in one portion with stirring. After 10 min at room temperature the mixture was diluted with saturated ammonium chloride solution and the product was extracted with ether. After drying, over magnesium sulfate the solvent was removed in vacuo and the residue was recrystallized from 80% methanol to afford 3-Amino-2-carboethoxyindole as a tan solid.
후처리
- extractionthe product was extracted with ether
- dry with materialAfter drying, over magnesium sulfate the solvent
- customwas removed in vacuo
- customthe residue was recrystallized from 80% methanol
출처 및 근거
- ORD 기록
- ord-b79ec306670a46739f4729534174e271
- 출처 데이터셋
- uspto-grants-1995_10
- 특허 번호
- US05463054
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