참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Ammonia | HCID 222 | — |
| 반응물 | Phosphorus oxychloride | HCID 24813 | — |
| 반응물 | ethyl 3-benzamido-1H-indole-2-carboxylate | HCID 2157323 | — |
| 용매 | Isopropanol | HCID 3776 | — |
| 생성물 | 3-Benzamidoindole-2-carboxamide | HCID 15284725 | — |
반응 단계
A mixture of 3-Benzamido-2-carboethoxyindole (3.0 g) and phosphorous oxychloride (20 mL) was refluxed for 30 min. The reaction mixture was concentrated in vacuo and the residue was triturated with ether to afford a white solid. This solid was treated with 40 mL of isopropanol which had been previously saturated with ammonia and heated in a sealed tube at 120° C. for 40 min. The reaction mixture was again concentrated in vacuo and the residue was triturated with ether to afford 3-Benzamido-indole-2-carboxamide as a white solid.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US05463054 |
|---|
| 출처 데이터셋 | uspto-grants-1995_10 |
|---|
| ORD ID | ord-1ecde341c4ab414eb4b53fe74e156fa9 |
|---|
| 출처 메모 | uspto-grants-1995_10 |
|---|
