Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
p-Bromobenzenesulfonyl chloride → Methyl 6-(2-(4-bromobenzenesulphonylamino)indan-5-yl)-6-(3-pyridyl)hex-5-enoate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | p-Bromobenzenesulfonyl chloride | HCID 7396 | — |
| 반응물 | Triethylamine | HCID 8471 | — |
| 반응물 | Methyl 6-(2-aminoindan-5-yl)-6-(3-pyridyl)hex-5-enoate | HCID 54311386 | — |
| 용매 | Chloroform | HCID 6212 | — |
| 생성물 | Methyl 6-(2-(4-bromobenzenesulphonylamino)indan-5-yl)-6-(3-pyridyl)hex-5-enoate | HCID 53803137 | — |
반응 단계
3.4 g of methyl 6-(2-aminoindan-5-yl)-6-(3-pyridyl)hex-5-enoate is placed in 40 ml of chloroform together with 3.3 g of 4-bromobenzenesulphonic acid chloride and 1.8 g of triethylamine are added in batches at ambient temperature. After 30 minutes the solution is washed with water, dried and rotary evaporated. The yellow oil is then chromatographed over a silica gel column using cyclohexane/ethyl acetate (1:2).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05426119 |
| 출처 데이터셋 | uspto-grants-1995_06 |
| ORD ID | ord-17636f13b32841d99940698ac3d7ea3d |
| 출처 메모 | uspto-grants-1995_06 |