Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Thionyl Chloride → 5-(Chloromethyl)uracil
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Thionyl Chloride | HCID 24386 | — |
| 반응물 | 5-(Hydroxymethyl)uracil | HCID 78168 | — |
| 용매 | 1,4-Dioxane | HCID 31275 | — |
| 생성물 | 5-(Chloromethyl)uracil | HCID 236125 | 100% |
반응 단계
Thionyl chloride ((10 ml) was added to a suspension of 5-(hydroxymethyl)-2,4(1H,3H)-pyrimidinedione (0.60 g, 4.2 mmol)from step (11a) in dioxane (15 ml). The reaction was heated to reflux for 4 h, allowed to cool, and concentrated in vacuo to give the 5-(chloromethyl)-2,4(1H,3H)-pyrimidinedione (0.62 g, 100%) as a yellow solid.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07101883B2 |
| 출처 데이터셋 | uspto-grants-2006_09 |
| ORD ID | ord-7ba52a75ba89449ebaa88639d2057de4 |
| 출처 메모 | uspto-grants-2006_09 |