Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Sodium Azide → 5-(azidomethyl)-2,4(1H,3H)-pyrimidinedione
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Sodium Azide | HCID 33557 | — |
| 반응물 | 5-(Chloromethyl)uracil | HCID 236125 | — |
| 용매 | Dimethyl Sulfoxide | HCID 679 | — |
| 생성물 | 5-(azidomethyl)-2,4(1H,3H)-pyrimidinedione | HCID 21963027 | 98.5% |
반응 단계
Sodium azide (0.6 g, 9.34 mmol) was added to a solution of 5-(chloromethyl)-2,4(1H,3H)-pyrimidinedione (0.3 g, 1.67 mmol) in DMSO (5 ml) under nitrogen at room temperature. The reaction was stirred for 2 h then partitioned between ethyl acetate and water. The organic layer was washed with brine, dried over magnesium sulfate and concentrated to give the 5-(azidomethyl)-2,4(1H,3H)-pyrimidinedione (0.275 g, 98%) as a yellow solid.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07101883B2 |
| 출처 데이터셋 | uspto-grants-2006_09 |
| ORD ID | ord-22f7f1367d0f4603af5b503bf3ddbb77 |
| 출처 메모 | uspto-grants-2006_09 |