(2E)-3-(4-((Methylsulfonyl)oxy)phenyl)-2-propenoic acid → (E)-3-(4-(trifluoromethylsulfonyloxy)phenyl)acrylic acid

반응식

CS(O[C:6]1[CH:11]=[CH:10][C:9](/[CH:12]=[CH:13]/[C:14]([OH:16])=[O:15])=[CH:8][CH:7]=1)(=O)=O.CS(Cl)(=O)=O.[F:22][C:23]([F:36])([F:35])[S:24]([O:27]S(C(F)(F)F)(=O)=O)(=[O:26])=[O:25]>>[F:22][C:23]([F:36])([F:35])[S:24]([O:27][C:6]1[CH:11]=[CH:10][C:9](/[CH:12]=[CH:13]/[C:14]([OH:16])=[O:15])=[CH:8][CH:7]=1)(=[O:26])=[O:25]

참가 물질

반응물 2

HCID 15726601(2E)-3-(4-((Methylsulfonyl)oxy)phenyl)-2-propenoic acid

HCID 86589944Trifluoromethansulfonic acid anhydride methanesulfonyl chloride

생성물 1

HCID 21964125(E)-3-(4-(trifluoromethylsulfonyloxy)phenyl)acrylic acid

실험 절차

13.4 g of (E)-3-(4-(trifluoromethylsulfonyloxy)phenyl)acrylic acid was synthesized as described for (E)-3-(4-(methanesulfonyloxy)phenyl)acrylic acid using trifluoromethansulfonic acid anhydride methanesulfonyl chloride.

출처 및 근거

ORD 기록: ord-d9d34d4d76dc4bf28262886936d523c5
출처 데이터셋: uspto-grants-2006_09
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07101898B2

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