Triethylamine → Methanesulfonic acid 3-benzenesulfonyl-3-methylbutyl ester

HRID 2212070노트

반응식

HRID 2212070 반응식
[C:1]1([S:7]([C:10]([CH3:15])([CH3:14])[CH2:11][CH2:12][OH:13])(=[O:9])=[O:8])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.C(N(CC)CC)C.[CH3:23][S:24](Cl)(=[O:26])=[O:25]>>[C:1]1([S:7]([C:10]([CH3:15])([CH3:14])[CH2:11][CH2:12][O:13][S:24]([CH3:23])(=[O:26])=[O:25])(=[O:8])=[O:9])[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

참가 물질

4

반응물 3

HCID 8471TriethylamineHCID 31297Methanesulfonyl chlorideHCID 149069793-Benzenesulfonyl-3-methyl-butan-1-ol

생성물 1

HCID 86595010Methanesulfonic acid 3-benzenesulfonyl-3-methylbutyl ester수율 103.1%

실험 절차

A solution of 3-benzenesulfonyl-3-methyl-butan-1-ol (2.17 g, 9.5 mmol), triethylamine (2.0 ml, 14.25 mmol), methanesulphonyl chloride (0.9 ml, 11.78 mmol) and 4-N,N-dimethylaminopyridine (12 mg, 0.01 mmol) was stirred at 0° C. for 45 min. After quenching with satd. NaHCO3, the mixture was extracted into dichloromethane. The combined organic extracts were dried (Na2SO4) and concentrated to give the title product (3.0 g).

후처리

  1. customAfter quenching with satd
  2. extractionNaHCO3, the mixture was extracted into dichloromethane
  3. dry with materialThe combined organic extracts were dried (Na2SO4)
  4. concentrationconcentrated

출처 및 근거

ORD 기록
ord-4f69f1bcb9d44b4b9564223aaaf7654c
출처 데이터셋
uspto-grants-2006_09
특허 번호
US07101892B2

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