Butenyl chloroformate → HCID 178454242, 화합물

HRID 2212115

반응식

HRID 2212115 반응식
[Cl:1][C:2]1[CH:3]=[C:4]([N:9]2[C:13](=[O:14])[C:12](=[O:15])[N:11]=[C:10]2[NH:16][C:17]([NH:19][CH:20]([CH3:22])[CH3:21])=[NH:18])[CH:5]=[CH:6][C:7]=1[Cl:8].Cl[C:24]([O:26][CH:27]=[CH:28][CH2:29][CH3:30])=[O:25]>>[Cl:1][C:2]1[CH:3]=[C:4]([N:9]2[C:13](=[O:14])[C:12](=[O:15])[NH:11][C:10]2=[N:16][C:17]([NH:19][CH:20]([CH3:22])[CH3:21])=[N:18][C:24]([O:26][CH2:27][CH2:28][CH:29]=[CH2:30])=[O:25])[CH:5]=[CH:6][C:7]=1[Cl:8]

참가 물질

3

반응물 2

HCID 53921054Butenyl chloroformateHCID 178457580HCID 178457580, 화합물

생성물 1

HCID 178454242HCID 178454242, 화합물

실험 절차

Compound 4g was prepared by the same method for preparation of 4b, using pure compound 4 (0.200 g, 585 mmol) and butenyl chloroformate as starting materials to yield compound 4g as a white color solid (98 mg, 38%). 1H NMR (300 MHz, CDCl3) δ 12.46 (s, 1H), 9.22 (s, 1H), 7.56–7.53 (m, 2H), 7.30–7.26 (dd, J=8.6 and 2.4 Hz, 1H), 5.85–5.72 (m, 1H), 5.20–5.13 (m, 2H), 4.29 (t, J=6.9 Hz, 2H), 4.16 (m, 1H), 2.47 (q, J=6.8 Hz, 2H), 1.24 (d, J=6.6 Hz, 6H); 13C NMR: δ170.76, 168.08, 159.19, 155.88, 153.96, 132.63, 132.53, 131.26, 130.40, 128.61, 125.65, 118.32, 66.60, 45.23, 32.74, 22.27; MS m/z 440 (M+), 388, 338, 269, 245, 180, 159.

출처 및 근거

ORD 기록
ord-1ed462078a804255bced0d8418293181
출처 데이터셋
uspto-grants-2006_09
특허 번호
US07101902B2

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