3-(4-Benzyloxy-phenyl)-3-hydroxy-2-methyl-propionic acid methyl ester → 3-Hydroxy-3-(4-hydroxy-phenyl)-2-methyl-propionic acid methyl ester

HRID 2212565노트

반응식

HRID 2212565 반응식
[CH3:1][O:2][C:3](=[O:22])[CH:4]([CH3:21])[CH:5]([C:7]1[CH:12]=[CH:11][C:10]([O:13]CC2C=CC=CC=2)=[CH:9][CH:8]=1)[OH:6].[H][H]>CO.[Pd]>[CH3:1][O:2][C:3](=[O:22])[CH:4]([CH3:21])[CH:5]([OH:6])[C:7]1[CH:12]=[CH:11][C:10]([OH:13])=[CH:9][CH:8]=1

참가 물질

5

반응물 2

HCID 695964413-(4-Benzyloxy-phenyl)-3-hydroxy-2-methyl-propionic acid methyl esterHCID 178418361HCID 178418361, 화합물

생성물 1

HCID 623934773-Hydroxy-3-(4-hydroxy-phenyl)-2-methyl-propionic acid methyl ester수율 104.6%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 887Methanol용매

실험 절차

10% Pd/C was added to a degassed solution of 3-(4-benzyloxy-phenyl)-3-hydroxy-2-methyl-propionic acid methyl ester (0.335 g, 1.1 mmol) in methanol (30 mL) and charged to 50 PSI hydrogen, then shaken for 2.5 h. The reaction was filtered to remove the catalyst and concentrated to give 3-hydroxy-3-(4-hydroxy-phenyl)-2-methyl-propionic acid methyl ester (0.242 g, 100%) as an oil. MS found: (M+H)+=211.

후처리

  1. filtrationThe reaction was filtered
  2. customto remove the catalyst
  3. concentrationconcentrated

출처 및 근거

ORD 기록
ord-91687b1e531340e6bd403277c77ffb25
출처 데이터셋
uspto-grants-2006_09
특허 번호
US07102008B2

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