Tetrabutylammonium Fluoride → HCID 69596295, 화합물

HRID 2212570노트

반응식

HRID 2212570 반응식
[F-].C([N+](CCCC)(CCCC)CCCC)CCC.[CH2:19]([O:21][C:22](=[O:46])[C:23]([CH3:45])([CH3:44])[C:24]([C:26]1[CH:35]=[CH:34][C:33]2[C:28](=[CH:29][CH:30]=[C:31]([O:36][Si](C(C)(C)C)(C)C)[CH:32]=2)[CH:27]=1)=[O:25])[CH3:20]>C1COCC1.C(OCC)(=O)C>[CH2:19]([O:21][C:22](=[O:46])[C:23]([CH3:45])([CH3:44])[C:24]([C:26]1[CH:35]=[CH:34][C:33]2[C:28](=[CH:29][CH:30]=[C:31]([OH:36])[CH:32]=2)[CH:27]=1)=[O:25])[CH3:20]

참가 물질

5

반응물 2

HCID 2724141Tetrabutylammonium FluorideHCID 69596330HCID 69596330, 화합물

생성물 1

HCID 69596295HCID 69596295, 화합물

시약·촉매·용매 2

HCID 8028Tetrahydrofuran용매2회HCID 8857Ethyl Acetate용매

실험 절차

Tetrabutylammonium floride 1M in THF (78 mL, 78 mmol) was added to a solution of 3-[6-(tert-butyl-dimethyl-silanyloxy)-naphthalen-2-yl]-2,2-dimethyl-3-oxo-propionic acid ethyl ester (77.1 mmol) in THF (300 mL) at room temperature for 0.5 h. The reaction was taken up in ethyl acetate, washed with water (2×) and brine, dried over magnesium sulfate, and concentrated to give the 3-(6-Hydroxy-naphthalen-2-yl)-2,2-dimethyl-3-oxo-propionic acid ethyl ester as a crude oil.

후처리

  1. washwashed with water (2×) and brine
  2. dry with materialdried over magnesium sulfate
  3. concentrationconcentrated

출처 및 근거

ORD 기록
ord-be48f4a8c89246979d9d795ff36f331d
출처 데이터셋
uspto-grants-2006_09
특허 번호
US07102008B2

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