Pyridiniumtribromide → 3-Bromo-2,5-difluoro-4-hydroxybenzaldehyde

HRID 2212594노트

반응식

HRID 2212594 반응식
[F:1][C:2]1[CH:9]=[C:8]([OH:10])[C:7]([F:11])=[CH:6][C:3]=1[CH:4]=[O:5].[Br-:12].[Br-].[Br-].[NH+]1C=CC=CC=1.[NH+]1C=CC=CC=1.[NH+]1C=CC=CC=1>ClCCl>[Br:12][C:9]1[C:2]([F:1])=[C:3]([CH:6]=[C:7]([F:11])[C:8]=1[OH:10])[CH:4]=[O:5]

참가 물질

4

반응물 2

HCID 21124087PyridiniumtribromideHCID 219664622,5-Difluoro-4-hydroxybenzaldehyde

생성물 1

HCID 219664683-Bromo-2,5-difluoro-4-hydroxybenzaldehyde수율 86,169.102%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

반응 조건

온도
40 °C

실험 절차

To a solution of 2,5-difluoro-4-hydroxybenzaldehyde (37.5 g, 0.237 mmol) in dichloromethane (1.5 L) was added pyridinium tribromide (75.9 g, 0.237 mmol). The reaction mixture was stirred at 40° C. for 7 hrs then at room temperature overnight. The reaction was washed with water and brine, dried over magnesium sulfate, filtered and evaporated to give 48.4 g of crude 3-bromo-2,5-difluoro-4-hydroxybenzaldehyde use as this in the next step.

후처리

  1. customat room temperature
  2. customovernight
  3. washThe reaction was washed with water and brine
  4. dry with materialdried over magnesium sulfate
  5. filtrationfiltered
  6. customevaporated

출처 및 근거

ORD 기록
ord-3b3a167c1c65433486f8a9691f5fee0a
출처 데이터셋
uspto-grants-2006_09
특허 번호
US07102000B2

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