Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Diethylamine → 6-(4-(2-(4-Chlorobenzenesulphonylamino)ethyl)phenyl)-6-(3-pyridyl)-hex-5-enoic acid diethylamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Diethylamine | HCID 8021 | — |
| 반응물 | 6-(4-(2-(4-Chlorobenzenesulphonylamino)ethyl)-phenyl)-6-(3-pyridyl)hex-5-enoic acid | HCID 65971 | — |
| 반응물 | 1,1'-Carbonyldiimidazole | HCID 68263 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 생성물 | 6-(4-(2-(4-Chlorobenzenesulphonylamino)ethyl)phenyl)-6-(3-pyridyl)-hex-5-enoic acid diethylamide | HCID 54283860 | — |
반응 단계
1.0 g of 6-(4-(2-(4-chlorobenzenesulphonylamino)ethyl)phenyl)-6-(3-pyridyl)hex-5-enoic acid are dissolved in 15 ml of tetrahydrofuran and stirred for 15 minutes with 0.49 g of carbonyldiimidazole. Then 1 ml of diethylamine is added and the mixture is refluxed for 2 hours. It is then concentrated by evaporation and the residue is taken up in ethyl acetate and dried. Finally, it is chromatographed over a silica gel column using ethyl acetate as eluant.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05426119 |
| 출처 데이터셋 | uspto-grants-1995_06 |
| ORD ID | ord-5433ee780de24cf1be55bf1100c617d0 |
| 출처 메모 | uspto-grants-1995_06 |