Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Aniline → 7-Phenyliminomethylcamptothecin
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Aniline | HCID 6115 | — |
| 반응물 | Ytterbium | HCID 23992 | — |
| 반응물 | 1H-Pyrano(3',4':6,7)indolizino(1,2-b)quinoline-11-carboxaldehyde, 4-ethyl-3,4,12,14-tetrahydro-4-hydroxy-3,14-dioxo-, (S)- | HCID 149876 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | 7-Phenyliminomethylcamptothecin | HCID 9868433 | 51.1% |
반응 단계
100 mg (0.26 mmoles) of 7-formylcamptothecin, dissolved into 20 ml of methylene chloride, and 25 μl (0.26 mmoles) of aniline, dissolved into 0.5 ml of methylene chloride, were added to a suspension of ytterbium triphlate (16.5 mg. 0.026 mmoles, 10% mol) in 5 ml of methylene chloride containing MS 4A and were left 3.5 hours under stirring at room T, then the solvent was evaporated under vacuum. The product was purified by means of flash chromatography on silica gel using a mixture of methylene chloride/methanol 98/2 as eluant. 60 mg of a yellow solid were obtained.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07105492B2 |
| 출처 데이터셋 | uspto-grants-2006_09 |
| ORD ID | ord-fe2875e78d884eb89e45d3ccbabf7e39 |
| 출처 메모 | uspto-grants-2006_09 |