Dicyclohexylcarbodiimide → Benzoic acid, 3-amino-5-nitro-, ethyl ester

HRID 2212842

반응식

HRID 2212842 반응식
[NH2:1][C:2]1[CH:3]=[C:4]([CH:8]=[C:9]([N+:11]([O-:13])=[O:12])[CH:10]=1)[C:5]([OH:7])=[O:6].[CH2:14]1CCC(N=C=NC2CCCCC2)C[CH2:15]1>CCO>[CH2:14]([O:6][C:5](=[O:7])[C:4]1[CH:8]=[C:9]([N+:11]([O-:13])=[O:12])[CH:10]=[C:2]([NH2:1])[CH:3]=1)[CH3:15]

참가 물질

4

반응물 2

HCID 10868DicyclohexylcarbodiimideHCID 2393423-Amino-5-nitrobenzoic acid

생성물 1

HCID 826201Benzoic acid, 3-amino-5-nitro-, ethyl ester

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

3-Amino-5-nitrobenzoic acid (910 mg, 5.0 mmol) was dissolved in EtOH (25 mL). DCC (1.51 g, 7.3 mmol) was added, and the mixture was stirred under reflux overnight. The solid precipitation was filtered off and the filtrate was evaporated. The residue was triturated in the solvent mixture ether:hexane:ethyl acetate, 5:5:1. The title compound was isolated as a fine light yellow powder (0.9 g, 85.7%).

후처리

  1. temperatureunder reflux overnight
  2. customThe solid precipitation
  3. filtrationwas filtered off
  4. customthe filtrate was evaporated
  5. customThe residue was triturated in the solvent mixture ether

출처 및 근거

ORD 기록
ord-7e16ced096ee4eabba61e01d23bdef25
출처 데이터셋
uspto-grants-2006_09
특허 번호
US07105503B2

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