Triethylamine → Allyl(cyclopentyl)carbamoyl chloride

HRID 2212961노트

반응식

HRID 2212961 반응식
[Cl:1][C:2]([O:5]C=O)(Cl)Cl.[CH2:8]([NH:11][CH:12]1[CH2:16][CH2:15][CH2:14][CH2:13]1)[CH:9]=[CH2:10].C(N(CC)CC)C>ClCCl>[CH2:8]([N:11]([CH:12]1[CH2:16][CH2:15][CH2:14][CH2:13]1)[C:2]([Cl:1])=[O:5])[CH:9]=[CH2:10]

참가 물질

5

반응물 3

HCID 8471TriethylamineHCID 5062349N-(prop-2-en-1-yl)cyclopentanamineHCID 13647314Trichloromethylformate

생성물 1

HCID 21956032Allyl(cyclopentyl)carbamoyl chloride

시약·촉매·용매 1

HCID 6344Dichloromethane용매

반응 조건

온도
0 °C

실험 절차

790 mg (0.48 ml, 3.99 mmol) of trichloromethylformate (“diphosgene”) are dissolved in 15 ml of dichloromethane and cooled to 0° C. To this are slowly added dropwise 1.00 g (1.17 ml, 7.986 mmol) of allyl(cyclopentyl)amine and 1.21 g (1.67 ml, 12.0 mmol) of triethylamine, and the mixture is left to stir at room temperature overnight. For workup, the reaction solution is poured into ice-water, extracted three times with dichloromethane, dried over MgSO4 and concentrated. The crude product is employed directly in the next stage.

후처리

  1. waitthe mixture is left
  2. extractionextracted three times with dichloromethane
  3. dry with materialdried over MgSO4
  4. concentrationconcentrated

출처 및 근거

ORD 기록
ord-6bd1d989f1044dfabad2edb70b54b3ef
출처 데이터셋
uspto-grants-2006_09
특허 번호
US07105523B2

반응 노트

불러오는 중…