Acetic acid, 2-(triphenylphosphoranylidene)-, ethyl ester → HCID 21956511, 화합물

HRID 2213100노트

반응식

HRID 2213100 반응식
[CH2:1]([O:3][C:4](=[O:25])[CH:5]=P(C1C=CC=CC=1)(C1C=CC=CC=1)C1C=CC=CC=1)[CH3:2].[CH3:26][O:27][C:28]1[CH:29]=[C:30]([CH:33]=[CH:34][C:35]=1[C:36]1[CH:41]=[CH:40][CH:39]=[CH:38][N:37]=1)[CH:31]=O>C(Cl)Cl>[CH3:26][O:27][C:28]1[CH:29]=[C:30](/[CH:31]=[CH:5]/[C:4]([O:3][CH2:1][CH3:2])=[O:25])[CH:33]=[CH:34][C:35]=1[C:36]1[CH:41]=[CH:40][CH:39]=[CH:38][N:37]=1

참가 물질

4

반응물 2

HCID 70670Acetic acid, 2-(triphenylphosphoranylidene)-, ethyl esterHCID 219565123-Methoxy-4-pyridin-2-ylbenzaldehyde

생성물 1

HCID 21956511HCID 21956511, 화합물

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

Ethyl(triphenylphosphoranylidene)acetate (550 mg, 1.6 mmol) and 3-methoxy-4-pyridin-2-ylbenzaldehyde (225 mg, 1.1 mmol) were dissolved in CH2Cl2 (5 mL) and stirred at rt for 12 h. The reaction mixture was concentrated and purified by flash column chromatography on silica gel eluting with EtOAc:hexanes (1:9 to 2:3) to afford the desired ethyl(2E)-3-(3-methoxy-4-pyridin-2-ylphenyl)prop-2-enoate.

후처리

  1. concentrationThe reaction mixture was concentrated
  2. custompurified by flash column chromatography on silica gel eluting with EtOAc:hexanes (1:9 to 2:3)

출처 및 근거

ORD 기록
ord-16d5cf6f80ba4be0810740c32e6b139d
출처 데이터셋
uspto-grants-2006_09
특허 번호
US07105533B2

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