Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Water → tert-Butyl [4-(1H-benzimidazol-2-yl)-1,3-thiazol-2-yl]methyl-carbamate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Water | HCID 962 | — |
| 반응물 | 1,2-Phenylenediamine dihydrochloride | HCID 11990 | — |
| 반응물 | Tert-butyl ((4-cyanothiazol-2-YL)methyl)carbamate | HCID 22560011 | — |
| 반응물 | HCID 178418582 | HCID 178418582 | — |
| 용매 | Methanol | HCID 887 | — |
| 생성물 | tert-Butyl [4-(1H-benzimidazol-2-yl)-1,3-thiazol-2-yl]methyl-carbamate | HCID 86760240 | — |
반응 단계
In analogy to the preparation of 8, 1.89 g of a 30% NaOCH3 solution were added to tert-butyl (4-cyano-1,3-thiazol-2-yl)methylcarbamate (2.5 g; 10.45 mmol) in 25 ml of CH3OH, and the mixture was stirred at room temperature for 2 h. Addition of 1.9 g of 1,2-phenylenediamine bishydrochloride was followed by stirring overnight, and then the reaction mixture was added to 100 ml of H2O, and the solid resulting after filtration was dried in vacuo.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07105508B1 |
| 출처 데이터셋 | uspto-grants-2006_09 |
| ORD ID | ord-f5ebaded0d65491ca59edccccd7fba4b |
| 출처 메모 | uspto-grants-2006_09 |