Water → tert-Butyl [4-(1H-benzimidazol-2-yl)-1,3-thiazol-2-yl]methyl-carbamate

HRID 2213151

반응식

HRID 2213151 반응식
O(C)[Na].[C:4]([C:6]1[N:7]=[C:8]([CH2:11][NH:12][C:13](=[O:19])[O:14][C:15]([CH3:18])([CH3:17])[CH3:16])[S:9][CH:10]=1)#[N:5].Cl.Cl.[C:22]1(N)[CH:27]=[CH:26][CH:25]=[CH:24][C:23]=1[NH2:28].O>CO>[NH:5]1[C:22]2[CH:27]=[CH:26][CH:25]=[CH:24][C:23]=2[N:28]=[C:4]1[C:6]1[N:7]=[C:8]([CH2:11][NH:12][C:13](=[O:19])[O:14][C:15]([CH3:16])([CH3:18])[CH3:17])[S:9][CH:10]=1

참가 물질

6

반응물 4

HCID 962WaterHCID 119901,2-Phenylenediamine dihydrochlorideHCID 22560011Tert-butyl ((4-cyanothiazol-2-YL)methyl)carbamateHCID 178418582HCID 178418582, 화합물

생성물 1

HCID 86760240tert-Butyl [4-(1H-benzimidazol-2-yl)-1,3-thiazol-2-yl]methyl-carbamate

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

In analogy to the preparation of 8, 1.89 g of a 30% NaOCH3 solution were added to tert-butyl (4-cyano-1,3-thiazol-2-yl)methylcarbamate (2.5 g; 10.45 mmol) in 25 ml of CH3OH, and the mixture was stirred at room temperature for 2 h. Addition of 1.9 g of 1,2-phenylenediamine bishydrochloride was followed by stirring overnight, and then the reaction mixture was added to 100 ml of H2O, and the solid resulting after filtration was dried in vacuo.

후처리

  1. stirringby stirring overnight
  2. customthe solid resulting
  3. filtrationafter filtration
  4. customwas dried in vacuo

출처 및 근거

ORD 기록
ord-f5ebaded0d65491ca59edccccd7fba4b
출처 데이터셋
uspto-grants-2006_09
특허 번호
US07105508B1

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