5-Bromoisatin → HCID 178504804, 화합물

HRID 2213209

반응식

HRID 2213209 반응식
[Br:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][C:6](=[O:11])[C:5]2=O.[CH3:13][S:14]([C:17]1[CH:22]=[CH:21][C:20]([NH:23][NH2:24])=[CH:19][CH:18]=1)(=[O:16])=[O:15]>>[Br:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][C:6](=[O:11])[C:5]2=[N:24][NH:23][C:20]1[CH:19]=[CH:18][C:17]([S:14]([CH3:13])(=[O:16])=[O:15])=[CH:22][CH:21]=1

참가 물질

3

반응물 2

HCID 68895-BromoisatinHCID 701424-(Methylsulphonyl)phenylhydrazine

생성물 1

HCID 178504804HCID 178504804, 화합물수율 72%

실험 절차

The title compound was prepared in 72% yield from 5-bromo-1H-indole-2,3-dione (Meth-Cohn and Goon, Tetrahedron Letters 1996, 37, 9381–4) and 4-methylsulfonylphenylhydrazine according to Procedure G: 1H NMR (DMSO-d6): δ 12.7 (s, 1H), 11.3 (s, 1H), 7.9 (d, 2H), 7.7–7.8 (m, 3H), 7.4 (dd, 1H), 6.9 (d, 1H), 3.2 (s, 3H); ESI-MS m/z 392 (M−H)−.

출처 및 근거

ORD 기록
ord-4d95c40b20134530bc70b5774d8422df
출처 데이터셋
uspto-grants-2006_09
특허 번호
US07105529B2

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