Toluene → HCID 21957938, 화합물

HRID 2213656노트

반응식

HRID 2213656 반응식
[CH2:1]([N:8]1[CH:12]=[C:11]([CH2:13][NH:14][C:15]2[CH:20]=[CH:19][C:18](C(C)C)=[CH:17][CH:16]=2)[CH:10]=[N:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH:24]([C:27]1[CH:32]=[CH:31][CH:30]=[C:29]([CH:33]([CH3:35])[CH3:34])[C:28]=1[N:36]=[C:37]=[O:38])([CH3:26])[CH3:25].[C:39]1(C)[CH:44]=CC=C[CH:40]=1>>[CH2:1]([N:8]1[CH:12]=[C:11]([CH2:13][N:14]([C:15]2[CH:16]=[CH:17][CH:18]=[CH:19][C:20]=2[CH:39]([CH3:44])[CH3:40])[C:37]([NH:36][C:28]2[C:29]([CH:33]([CH3:34])[CH3:35])=[CH:30][CH:31]=[CH:32][C:27]=2[CH:24]([CH3:25])[CH3:26])=[O:38])[CH:10]=[N:9]1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

참가 물질

4

반응물 3

HCID 1140TolueneHCID 922592,6-Diisopropylphenyl isocyanateHCID 21957926HCID 21957926, 화합물

생성물 1

HCID 21957938HCID 21957938, 화합물

실험 절차

To a solution of [(1-benzylpyrazol-4-yl)methyl](4-isopropylphenyl)amine (0.17 g) in toluene (5 mL) was added 2,6-diisopropylphenyl isocyanate (0.12 mL) and the mixture was stirred overnight at room temperature. The reaction mixture was washed with saturated brine and dried over magnesium sulfate. The solvent was evaporated under reduced pressure and the residue was purified by silica gel column chromatography to give N-[(1-benzylpyrazol-4-yl)methyl]-N′-(2,6-diisopropylphenyl)-N-(isopropylphenyl)urea (0.24 g).

후처리

  1. washThe reaction mixture was washed with saturated brine
  2. dry with materialdried over magnesium sulfate
  3. customThe solvent was evaporated under reduced pressure
  4. customthe residue was purified by silica gel column chromatography

출처 및 근거

ORD 기록
ord-ef089b70f1ce4cba833edbf8a9a8f553
출처 데이터셋
uspto-grants-2006_09
특허 번호
US07105567B2

반응 노트

불러오는 중…