Tetrahydrofuran → 4-(1-Hydroxyethyl)-1-(dimethylethoxycarbonyl)imidazole
반응식
[CH3:1][C:2]([CH3:14])([O:4][C:5]([N:7]1[CH:11]=[C:10]([CH:12]=[O:13])[N:9]=[CH:8]1)=[O:6])[CH3:3].O1CCC[CH2:16]1>>[OH:13][CH:12]([C:10]1[N:9]=[CH:8][N:7]([C:5]([O:4][C:2]([CH3:14])([CH3:1])[CH3:3])=[O:6])[CH:11]=1)[CH3:16]참가 물질
3
실험 절차
To a solution of 1-(dimethylethoxycarbonyl)imidazole-4-carboxaldehyde (9.3 g, 47 mmol) in tetrahydrofuran (200 mL) was added a methyl Grignard reagent (6.6 mL, 50 mmol) at ambient temperature. The resulting reaction mixture was stirred overnight at ambient temperature. The reaction was quenched with water and extracted with ethyl acetate. The organic layer was dried (Na2SO4) and concentrated to afford 10 g of 4-(1-hydroxyethyl)-1-(dimethylethoxycarbonyl)imidazole as an oil.
후처리
- customThe resulting reaction mixture
- customThe reaction was quenched with water
- extractionextracted with ethyl acetate
- dry with materialThe organic layer was dried (Na2SO4)
- concentrationconcentrated
출처 및 근거
- ORD 기록
- ord-1272e2970fe64025ad7a0ca46b3d227f
- 출처 데이터셋
- uspto-grants-2006_09
- 특허 번호
- US07105563B2
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