4-(1-Hydroxyethyl)-1-(dimethylethoxycarbonyl)imidazole → tert-butyl 4-acetyl-1H-imidazole-1-carboxylate
반응식
[OH:1][CH:2]([C:4]1[N:5]=[CH:6][N:7]([C:9]([O:11][C:12]([CH3:15])([CH3:14])[CH3:13])=[O:10])[CH:8]=1)[CH3:3]>C(Cl)Cl.O=[Mn]=O>[C:2]([C:4]1[N:5]=[CH:6][N:7]([C:9]([O:11][C:12]([CH3:15])([CH3:14])[CH3:13])=[O:10])[CH:8]=1)(=[O:1])[CH3:3]참가 물질
4
실험 절차
4-(1-Hydroxyethyl)-1-(dimethylethoxycarbonyl)imidazole (8.7 g, 41 mmol) was dissolved in methylene chloride (100 mL) and MnO2 (10.7 g, 123 mmol) was added. The resulting reaction mixture was stirred overnight at ambient temperature. The reaction mixture was filtered, concentrated, and purified with silica column chromatography to afford 4 g of 4-acetyl-1-(dimethylethoxycarbonyl)imidazole and unreacted starting material.
후처리
- customThe resulting reaction mixture
- filtrationThe reaction mixture was filtered
- concentrationconcentrated
- custompurified with silica column chromatography
출처 및 근거
- ORD 기록
- ord-fee662d6d17347dd8b9e68680efda31c
- 출처 데이터셋
- uspto-grants-2006_09
- 특허 번호
- US07105563B2
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