Water → 2',4'-Difluoro-N-(3-(oxiran-2-yl)phenyl)biphenyl-4-sulfonamide

HRID 221391노트

반응식

HRID 221391 반응식
[F:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[C:9]1[CH:14]=[CH:13][C:12]([S:15]([NH:18][C:19]2[CH:24]=[CH:23][CH:22]=[C:21]([CH:25]=[CH2:26])[CH:20]=2)(=[O:17])=[O:16])=[CH:11][CH:10]=1.[OH2:27]>C(Cl)Cl>[F:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[C:9]1[CH:10]=[CH:11][C:12]([S:15]([NH:18][C:19]2[CH:24]=[CH:23][CH:22]=[C:21]([CH:25]3[CH2:26][O:27]3)[CH:20]=2)(=[O:16])=[O:17])=[CH:13][CH:14]=1

참가 물질

4

반응물 2

HCID 962WaterHCID 673295122',4'-Difluoro-N-(3-vinylphenyl)biphenyl-4-sulfonamide

생성물 1

HCID 866562622',4'-Difluoro-N-(3-(oxiran-2-yl)phenyl)biphenyl-4-sulfonamide

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

Dry meta-chloroperoxybenzoic acid (˜85%, dried over KOH in a clean, dry, uncontaminated vacuum desiccator for at least 48 hours; 3.7 g, 21 mmol) was added to a solution of 2′,4′-difluoro-N-(3-vinylphenyl)biphenyl-4-sulfonamide (1.16 g, 4.3 mmol) in dry DCM (30 mL) at 0° C. The mixture was allowed to warm to room temperature and stirred for 5 hours. Water (30 mL) was added and the layers were separated. The DCM layer was washed with 10% Na2SO3 (30 mL), saturated NaHCO3 (30 mL), water (30 mL) and brine (30 mL) and dried over MgSO4. The solvent was evaporated and the title compound obtained as an orange oil (1.16 g) which was used without further purification.

후처리

  1. dry with materialDry meta-chloroperoxybenzoic acid (˜85%, dried over KOH in a clean,
  2. customdry
  3. waituncontaminated vacuum desiccator for at least 48 hours
  4. customthe layers were separated
  5. washThe DCM layer was washed with 10% Na2SO3 (30 mL), saturated NaHCO3 (30 mL), water (30 mL) and brine (30 mL)
  6. dry with materialdried over MgSO4
  7. customThe solvent was evaporated

출처 및 근거

ORD 기록
ord-b0b567b37f1345a59fe7ff70b1aa8a2b
출처 데이터셋
uspto-grants-2012_06
특허 번호
US08207167B2

반응 노트

불러오는 중…