p-Bromobenzenesulfonyl chloride → 3-{[(4-Bromophenyl)sulfonyl]amino}-2-methylbenzoic acid

HRID 221414

반응식

HRID 221414 반응식
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([S:8](Cl)(=[O:10])=[O:9])=[CH:4][CH:3]=1.[NH2:12][C:13]1[C:14]([CH3:22])=[C:15]([CH:19]=[CH:20][CH:21]=1)[C:16]([OH:18])=[O:17]>N1C=CC=CC=1>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([S:8]([NH:12][C:13]2[C:14]([CH3:22])=[C:15]([CH:19]=[CH:20][CH:21]=2)[C:16]([OH:18])=[O:17])(=[O:10])=[O:9])=[CH:4][CH:3]=1

참가 물질

4

반응물 2

HCID 7396p-Bromobenzenesulfonyl chlorideHCID 27336993-Amino-2-methylbenzoic acid

생성물 1

HCID 29734663-{[(4-Bromophenyl)sulfonyl]amino}-2-methylbenzoic acid

시약·촉매·용매 1

HCID 1049Pyridine용매

실험 절차

The title compound was prepared using a method analogous to Method A, using 4-bromobenzene sulfonyl chloride, 3-amino-2-methylbenzoic acid, and a large excess of pyridine. The title compound was precipitated on partition of the reaction mixture between dilute HCl and DCM. The precipitate was collected by filtration, dissolved in ethyl acetate and dried. Evaporation of the solvent gave the title compound as a pale brown solid.

후처리

  1. customThe title compound was prepared
  2. customThe title compound was precipitated
  3. customon partition of the reaction mixture between dilute HCl and DCM
  4. filtrationThe precipitate was collected by filtration
  5. dissolutiondissolved in ethyl acetate
  6. customdried
  7. customEvaporation of the solvent

출처 및 근거

ORD 기록
ord-b1f5b7534e04422fa63ba9a6169bfcbe
출처 데이터셋
uspto-grants-2012_06
특허 번호
US08207167B2

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